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psmb7

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Official Full Name
proteasome (prosome, macropain) subunit, beta type, 7
Background
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. A pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Jul 2012]
Synonyms
PSMB7; proteasome (prosome, macropain) subunit, beta type, 7; Z; proteasome subunit beta type-7; macropain chain Z; proteasome subunit Z; proteasome subunit alpha; proteasome catalytic subunit 2; multicatalytic endopeptidase complex chain Z; proteasome subunit beta 7; unp311; C167P9.3; zgc:110090

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