Polyserase3 and was originally discovered in human liver as a mosaic serine proteinase with two tandem repeats of serine proteinase domains. Polyserase3 is similar to polyserase1 and polyserase2, but lacks the transmembrane domain, SEA domain and LDL like domains of polyserase1. In addition, rather than the three serase domains of polyserase1 and polyserase2, polyserase3 has two serase domains. Also, polyserase3 appears to be mainly a non glycosylated secreted protein, while polyserase1 and polyserase2 are glycosylated. Polyserase3 message was found in greatest abundance in human placenta, liver, testis, muscle, heart, and in fetal brain, kidney, lung and liver. Several human tumor cell lines also express significant amounts of polyserase3. Polyserase3 is a secreted protein, unlike polyserase1, which is membrane associated.
PRSS53; protease, serine, 53; POL3S; UNQ308; serine protease 53; EDTP308; polyserase 3; polyserase-3; polyserine protease 3