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Official Full Name
protein Z, vitamin K-dependent plasma glycoprotein
Background
This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the;plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent;protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein;are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the;cause of protein Z deficiency. Alternate splicing results in multiple transcript variants.
Synonyms
PROZ; protein Z, vitamin K-dependent plasma glycoprotein; vitamin K-dependent protein Z; PZ; Protein Z, vitamin K dependent plasma glycoprotein; OTTHUMP00000018738; OTTHUMP00000018739

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