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Official Full Name
protein S (alpha)
Background
This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. [provided by RefSeq, Feb 2009]
Synonyms
PROS1; protein S (alpha); PSA; PROS; PS21; PS22; PS23; PS24; PS25; THPH5; THPH6; vitamin K-dependent protein S; protein Sa; vitamin K-dependent plasma protein S; zgc:154001

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