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prlr

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Official Full Name
prolactin receptor
Background
This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]
Synonyms
PRLR; prolactin receptor; HPRL; MFAB; hPRLrI; PRL-R; hPRL receptor; secreted prolactin binding protein; PRLR, hPRLrI; PRLRb; cPRLR; prolactin receptor b; equates to base 1078-1204 of D13154

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