Official Full Name
protein kinase, AMP-activated, alpha 2 catalytic subunit
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a;heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important;energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is;activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy;beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and;cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin;sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
PRKAA2; protein kinase, AMP-activated, alpha 2 catalytic subunit; PRKAA; 5-AMP-activated protein kinase catalytic subunit alpha-2; AMPK; AMPKa2; AMPK-alpha-2 chain; AMPK subunit alpha-2; 5-AMP-activated protein kinase, catalytic alpha-2 chain; AMPK2; 5-AMP-activated protein kinase alpha-2 catalytic subunit