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prdm2

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Official Full Name
PR domain containing 2, with ZNF domain
Background
This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Synonyms
PRDM2; PR domain containing 2, with ZNF domain; RIZ; KMT8; RIZ1; RIZ2; MTB-ZF; HUMHOXY1; PR domain zinc finger protein 2; MTE-binding protein; zinc finger protein RIZ; GATA-3 binding protein G3B; GATA-3-binding protein G3B; lysine N-methyltransferase 8; PR domain-containing protein 2; zinc-finger DNA-binding protein; retinoblastoma protein-binding zinc finger protein; retinoblastoma protein-interacting zinc finger protein