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ppm1d

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Official Full Name
protein phosphatase, Mg2+/Mn2+ dependent, 1D
Background
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]
Synonyms
PPM1D; protein phosphatase, Mg2+/Mn2+ dependent, 1D; WIP1; PP2C-DELTA; protein phosphatase 1D; protein phosphatase Wip1; wild-type p53-induced phosphatase 1; protein phosphatase 2C delta isoform; protein phosphatase 1D magnesium-dependent, delta isoform; protein phosphatase 1D magnesium dependent, delta isoform; PP2C DELTA; protein phosphatase 2C; delta isoform; wild type p53 induced phosphatase 1; protein phosphatase magnesium-dependent 1 delta

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