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Official Full Name
phosphoribosyl pyrophosphate amidotransferase
Background
The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region.
Synonyms
PPAT; phosphoribosyl pyrophosphate amidotransferase; amidophosphoribosyltransferase; GPAT; PRAT; Amidophosphoribosyltransferase [Precursor]; ATASE; Glutamine phosphoribosylpyrophosphate amidotransferase; Glutamine PRPP amidotransferase; glutamine phosphoribosylpyrophosphatate amidotransferase; im:6894693; wu:fb61f03; wu:fc28b09; si:dkeyp-117h8.5