This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
POU2F3; POU class 2 homeobox 3; POU domain class 2, transcription factor 3; POU domain, class 2, transcription factor 3; Epoc 1; OCT11; PLA 1; Skn 1a; Epoc1; HGNC19864; Oct 11; Octamer binding transcription factor 11; PLA1 protein; POU domain; POU transcription factor; Transcription factor Skn1; OTTHUMP00000231987; OTTHUMP00000231988; octamer-binding protein 11; transcription factor PLA-1; transcription factor Skn-1; POU domain transcription factor OCT11a; octamer-binding transcription factor 11; PLA1; PLA-1; Epoc-1; OCT-11; OTF-11; Skn-1a; zgc:136377; zgc:158534