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pot1

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Official Full Name
protection of telomeres 1
Background
This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
Synonyms
POT1; protection of telomeres 1; HPOT1; protection of telomeres protein 1; protection of telomeres 1 homolog; POT1-like telomere end-binding protein; protection of telomeres 1 homolog (S. pombe); DKFZp586D211; cPot1; POT1 protection of telomeres 1 homolog; single-strand telomeric DNA-binding protein

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