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polk

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Official Full Name
polymerase (DNA directed) kappa
Background
External and internal DNA-damaging agents continually threaten the integrity of genetic material in cells. Although a;variety of repair mechanisms exist to remove the resulting lesions, some lesions escape repair and block the;replication machinery. Members of the Y family of DNA polymerases, such as POLK, permit the continuity of the;replication fork by allowing replication through such DNA lesions. Each Y family polymerase has a unique DNA-damage;bypass and fidelity profile. POLK is specialized for the extension step of lesion bypass (summary by Lone et al., 2007;(PubMed 17317631)).
Synonyms
POLK; polymerase (DNA directed) kappa; DINB1; DNA polymerase kappa; DINB protein; DINP; POLQ