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polh

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Official Full Name
polymerase (DNA directed), eta
Background
This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. [provided by RefSeq, Jul 2008]
Synonyms
POLH; polymerase (DNA directed), eta; XPV; XP-V; RAD30; RAD30A; DNA polymerase eta; RAD30 homolog A; xeroderma pigmentosum variant type protein; XP V; FLJ16395; FLJ21978; polymerase eta; fc50a12; wu:fc50a12; zgc:136881; zgc:152642