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polg2

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Official Full Name
polymerase (DNA directed), gamma 2, accessory subunit
Background
DNA polymerasebeta is a distributive polymerase involved in base excision repair which repairs damaged DNA by excising modified bases (oxidized methylated deaminated etc.). It has single-strand DNA binding and deoxyribose phosphodiesterase activities on the N-terminal side and nucleotidyltransferase activity on the C-terminal side. The enzyme is constitutively expressed in growing cells but the level of expression is further increased by treatment with alkylating reagents such as MNNG and MMS.
Synonyms
POLG2; polymerase (DNA directed), gamma 2, accessory subunit; DNA polymerase subunit gamma-2, mitochondrial; HP55; MTPOLB; p55; mitochondrial DNA polymerase subunit gamma-2; DNA polymerase gamma accessory 55 kDa subunit; mitochondrial DNA polymerase accessory subunit; mitochondrial DNA polymerase, accessory subunit; POLB; PEOA4; POLGB; POLG-BETA

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