This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase;and 3 to 5 exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is;required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear;antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript;variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the;long arm of chromosome 5.
POLD2; polymerase (DNA directed), delta 2, regulatory subunit 50kDa; polymerase (DNA directed), delta 2, regulatory subunit (50kD); DNA polymerase delta subunit 2; DNA polymerase delta subunit p50; DNA polymerase subunit delta 2; DNA polymerase subunit delta p50; DPOD2_HUMAN; POLD 2; OTTHUMP00000159252; OTTHUMP00000209249; OTTHUMP00000209250; polymerase (DNA directed), delta 2, regulatory subunit; zgc:55633; zgc:77043; si:dz150f13.3