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pnpla2

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Official Full Name
patatin-like phospholipase domain containing 2
Background
Adipose Triglyceride Lipase (ATGL), an enzyme that catalyzes the rate limiting hydrolysis step of triglycerides in the triacylglycerol lipolysis cascade, is expressed predominantly in adipose tissue, but is also found in lesser amounts within cardiac and skeletal muscle. Its function is to initiate the breakdown of intracellular triglycerides into fatty acid monomers. Individuals deficient in the ATGL enzyme are at higher risk for cardiac dysfunction and premature death because of increased size and accumulation of lipid droplets within cardiac myocytes.
Synonyms
PNPLA2; patatin-like phospholipase domain containing 2; patatin-like phospholipase domain-containing protein 2; ATGL; desnutrin; FP17548; TTS 2.2; TTS2.2; IPLA2-zeta; triglyceride hydrolase; adipose triglyceride lipase; transport-secretion protein 2.2; pigment epithelium-derived factor; calcium-independent phospholipase A2; TTS2; PEDF-R; TTS-2.2; 1110001C14Rik; DKFZp667M109; PNPLA2/ATGL

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