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pms1

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Official Full Name
PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
Background
This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome.
Synonyms
PMS1; PMS1 postmeiotic segregation increased 1 (S. cerevisiae); PMSL1, postmeiotic segregation increased (S. cerevisiae) 1; PMS1 protein homolog 1; mismatch repair gene PMSL1; human homolog of yeast mutL; DNA mismatch repair protein PMS1; rhabdomyosarcom; rhabdomyosarcoma antigen MU-RMS-40.10B; rhabdomyosarcoma antigen MU-RMS-40.10E; PMSL1; hPMS1; HNPCC3; FLJ98259; DKFZp781M0253; si:dz72b14.2; si:dz164h20.2

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