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plau

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Official Full Name
plasminogen activator, urokinase
Background
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Synonyms
PLAU; PLAU plasminogen activator, urokinase; ATF; UPA; URK; u-PA urokinase-type plasminogen activator; OTTHUMP00000019849; OTTHUMP00000019850; OTTHUMP00000019851; U-plasminogen activator; plasminogen activator, urinary.; plasminogen activator, urokinase; urokinase-type plasminogen activator; plasminogen activator, urinary; QPD; u-PA; BDPLT5

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