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pla2g2a

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Official Full Name
phospholipase A2, group IIA (platelets, synovial fluid)
Background
Phospholipase A2 (PLA2) catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids. PLA2 (Type V) is a secretory PLA2 (sPLA2) of approximately 14 kDa and is one of the isoforms in the growing list of the PLA2 enzyme family.2 This enzyme, rather than the sPLA2 (Type II), is responsible for arachidonic acid mobilization leading to prostaglandin production in macrophages and mast cells. Consistent with this role, sPLA2 (Type V) is associated with the golgi apparatus, nuclear envelope, and plasma membrane in murine bone marrow-derived mast cells. sPLA2 (Type V) has been cloned from a variety of species including human, mouse, and rat. The enzyme is expressed in heart, lung, placenta, and spleen, as well as P388D1 macrophages and mast cells
Synonyms
PLA2G2A; phospholipase A2, group IIA (platelets, synovial fluid); phospholipase A2, membrane associated; GIIC sPLA2; enhancing factor; modifier of Min1; group IIA phospholipase A2; secretory group II phospholipase A2; phosphatidylcholine 2-acylhydrolase 2A; non-pancreatic secreted type II phospholipase A2; EF; Mom1; Pla2; sPLA2; sPla2-IIA; PLA2B, PLA2L; NPS-PLA2; non-pancreatic secretory phospholipase A2; PLA2B; PLA2L; PLA2S; PLAS1; IIE; secreted phospholipase A2