Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.
PILRA; paired immunoglobin-like type 2 receptor alpha; paired immunoglobulin-like type 2 receptor alpha; FDF03; Cell surface receptor FDF03; Inhibitory receptor PILR-alpha; paired immunoglobulin-like receptor alpha; PILRA_HUMAN; paired immunoglobin-like receptor alpha; OTTHUMP00000207544; OTTHUMP00000207543; OTTHUMP00000207542; OTTHUMP00000207541; inhibitory receptor PILRalpha; FDF03,PILRA