Creative biogene
SHARE THIS
facebook twitterlinkedingoogle plusStumbleUpon blog


Products
CBpromise

24x7 CUSTOMER SERVICE

CONTACT US TO ORDER

;

pilra

Bookmark and Share
Official Full Name
paired immunoglobin-like type 2 receptor alpha
Background
Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.
Synonyms
PILRA; paired immunoglobin-like type 2 receptor alpha; paired immunoglobulin-like type 2 receptor alpha; FDF03; Cell surface receptor FDF03; Inhibitory receptor PILR-alpha; paired immunoglobulin-like receptor alpha; PILRA_HUMAN; paired immunoglobin-like receptor alpha; OTTHUMP00000207544; OTTHUMP00000207543; OTTHUMP00000207542; OTTHUMP00000207541; inhibitory receptor PILRalpha; FDF03,PILRA

CONTACT CREATIVE BIOGENE

45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-097-1828

Terms & Conditions | Privacy Policy | Sitemap | FAQ | © 2010-2018 Creative Biogene. All Rights Reserved.