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piga

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Official Full Name
phosphatidylinositol glycan anchor biosynthesis, class A
Background
This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12. [provided by RefSeq, Jun 2010]
Synonyms
PIGA; phosphatidylinositol glycan anchor biosynthesis, class A; GPI3; PIG-A; MCAHS2; phosphatidylinositol N-acetylglucosaminyltransferase subunit A; GPI anchor biosynthesis; GLCNAC-PI synthesis protein; class A GlcNAc-inositol phospholipid assembly protein; phosphatidylinositol-glycan biosynthesis, class A protein; phosphatidylinositol glycan, class A (paroxysmal nocturnal hemoglobinuria); paroxysmal nocturnal hemoglobinuria; GPI3, PIG-A, MCAHS2; N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein; phosphatidylinositol glycan anchor biosynthesis, cl; zgc:56589; im:6911675

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