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pias3

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Official Full Name
protein inhibitor of activated STAT, 3
Background
This gene encodes a member of the PIAS (protein inhibitor of activated STAT (signal transducer and activator of;transcription)) family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like;modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It;directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced;transcript variants of this gene have been identified, but the full-length nature of some of these variants has not;been determined.
Synonyms
PIAS3; protein inhibitor of activated STAT, 3; E3 SUMO-protein ligase PIAS3; FLJ14651; zinc finger; MIZ type containing 5; ZMIZ5; zinc finger, MIZ-type containing 5; protein inhibitor of activated STAT protein 3