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phf1

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Official Full Name
PHD finger protein 1
Background
This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to double-strand breaks, and reduced protein levels results in X-ray sensitivity and increased homologous recombination. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms
PHF1; PHD finger protein 1; MTF2L2; hPCl1; polycomb-like protein 1; PCL1; PHF2