Official Full Name
Phosphofructokinase catalyzes the irreversible conversion of fructose 6 phosphate to fructose 1,6 bisphosphate. Mammalian PFK is a complex isozyme consisting of 3 subunits: muscle (M), liver (L), and platelet (P). Each subunit is encoded by a separate structural locus on chromosomes 1(M), 21(L), and 10(P). PFKL is the major form in liver and kidney while only M type PFK isozyme is expressed in mature muscle; therefore, muscle contains only homotetramers of M subunits. Erythrocytes contain both L and M subunits, and these randomly tetramerize to form M4, L4, and 3 additional hybrid forms of the holoenzyme.
Fructose-6-Phosphate Kinase; 6 Phosphofructokinase Muscle; EC 220.127.116.11; GSD7; MGC8699; PFKA; PFKL; PFKM; PFKP; PFKX; Phosphofructo 1 Kinase Isozyme A; Phosphofructokinase 1; Phosphofructokinase M; Phosphofructokinase muscle; Phosphofructokinase muscle type; Phosphofructokinase polypeptide X; Phosphohexokinase; 6-phosphofructokinase; phosphofructokinase; phosphofructokinase, muscle; PFKX, phosphofructokinase, polypeptide X; 6-phosphofructokinase, muscle type; PFK 1; PFK-A; phosphofructokinase-M; 6-phosphofructo-1-kinase; phosphofructo-1-kinase isozyme A; phosphofructokinase, polypeptide X; PFK1; PFK-1; GSD7, MGC8699, PFK-1, PFK1, PFKA, PFKX, PFKM