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peg3

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Official Full Name
paternally expressed 3
Background
Alternative-splicing factor 1 (ASF-1), also known as SRp30a or SF2, is a member of the highly conserved family of SR proteins, a group of serine/arginine-rich domain-containing proteins that play a critical role in regulated and constitutive splicing of precursor mRNA. The SR family of proteins is characterized as having one to two RNA recognition motifs located in the n-terminal sequence, and an RS domain within the C-terminus that is rich in serine/arginine dipeptide repeats. ASF-1 has an inhibitory role in exon skipping, in order to maintain splicing accuracy and to monitor alternative splicing. Studies have shown that ASF-1 plays a role in the regulation of caspase-9 alternative splicing as well as being a critical component for ceramide to function as a mediator of alternative splicing for the same caspase.
Synonyms
PEG3; paternally expressed 3; paternally-expressed gene 3 protein; KIAA0287; ZNF904; ZSCAN24; Kruppel-type zinc finger protein; zinc finger and SCAN domain-containing protein 24; PW1; DKFZp781A095

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