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pdzd3

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Official Full Name
PDZ domain containing 3
Background
Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421),followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 (PubMed 11950846)).
Synonyms
PDZD3; PDZ domain containing 3; PDZ domain containing 2 , PDZK2; Na(+)/H(+) exchange regulatory cofactor NHE-RF4; FLJ22756; IKEPP; Intestinal and kidney enriched PDZ protein; Intestinal and kidney-enriched PDZ protein; Na/Pi cotransporter C-terminal-associated protein 2; NaPi-Cap2; Natrium-phosphate cotransporter IIa C-terminal-associated protein 2; NHERF-4; NHRF4_HUMAN; PDZ domain containing protein 2; PDZ domain-containing protein 2; PDZ domain-containing protein 3; PDZD 3; PDZK2; Protein DLNB27; Sodium-hydrogen exchanger regulatory factor 4; PDZ domain containing 2; NHERF4