The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the;overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the;tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose;metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and;phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate;dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is;predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding;different isoforms have been found for this gene.
PDK3; pyruvate dehydrogenase kinase, isozyme 3; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial; mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3; PDK3_HUMAN; Pyruvate dehydrogenase kinase isoform 3; Pyruvate dehydrogenase kinase isozyme 3; Pyruvate dehydrogenase lipoamide kinase isozyme 3 mitochondrial; pyruvate dehydrogenase kinase, isoenzyme 3; pyruvate dehydrogenase, lipoamide, kinase isozyme 3, mitochondrial