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pdk2

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Official Full Name
pyruvate dehydrogenase kinase, isozyme 2
Background
This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms
PDK2; pyruvate dehydrogenase kinase, isozyme 2; pyruvate dehydrogenase kinase, isoenzyme 2; PDHK2; pyruvate dehydrogenase, lipoamide, kinase isozyme 2, mitochondrial