The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis.
PDGFRB; platelet derived growth factor receptor, beta polypeptide; beta-type platelet-derived growth factor receptor; CD140B; Beta platelet derived growth factor receptor; CD 140B; CD140 antigen-like family member B; CD140b antigen; JTK12; OTTHUMP00000160528; PDGF R beta; PDGF-R-beta; PDGFR; PDGFR1; PGFRB_HUMAN; Platelet derived growth factor receptor beta; Platelet derived growth factor receptor beta polypeptide; PDGF beta chain; OTTMUSP00000015854; OTTMUSP00000015855; platelet-derived growth factor receptor beta variant 1; AI528809; platelet-derived growth factor receptor, beta polypeptide; platelet-derived growth factor receptor beta; PDGFR-beta; platelet-derived growth factor receptor 1; PDGFR-1; JTK12, PDGFR, CD140B, PDGFR1, PDGF-R-beta; platelet-derived growth factor receptor beta 2; PDGF-beta