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pde11a

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Official Full Name
phosphodiesterase 11A
Background
The 3,5-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3,5-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms
PDE11A; phosphodiesterase 11A; dual 3,5-cyclic-AMP and -GMP phosphodiesterase 11A; cAMP and cGMP cyclic nucleotide phosphodiesterase 11A; PPNAD2; FLJ23693; MGC133355; MGC133356