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pcnt

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Official Full Name
pericentrin
Background
The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II.
Synonyms
PCNT; pericentrin; PCNT2, pericentrin 2 (kendrin); KEN; kendrin; KIAA0402; PCN; PCNTB; SCKL4; Seckel syndrome 4; pericentrin B; pericentrin-2; pericentrin-B; pericentrin-380; MOPD2; PCNT2; PCTN2

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