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pck1

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Official Full Name
phosphoenolpyruvate carboxykinase 1 (soluble)
Background
This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized. [provided by RefSeq, Jul 2008]
Synonyms
PCK1; phosphoenolpyruvate carboxykinase 1 (soluble); PEPCK1; PEPCKC; PEPCK-C; phosphoenolpyruvate carboxykinase, cytosolic [GTP]; PEP carboxykinase; phosphopyruvate carboxylase; phosphoenolpyruvate carboxylase; phosphoenolpyruvate carboxykinase, cytosolic; PEPCK; cytosolic phosphoenolpyruvate carboxykinase; cb856; cb924; fj93h11; zgc:63869; wu:fc51c05; wu:fj93h11

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