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pcdhgb1

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Official Full Name
protocadherin gamma subfamily B, 1
Background
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
Synonyms
PCDHGB1; protocadherin gamma subfamily B, 1; protocadherin gamma-B1; PCDH GAMMA B1; protocadherin gamma subfamily B; 1; isoform 2; MGC119466; MGC119467; MGC119469; Protocadherin gamma B1; Protocadherin gamma B1 precursor; Protocadherin gamma subfamily B 1; protocadherin gamma subfamily B, 1, isoform 2; PCDH-GAMMA-B1