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pcdhga5

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Official Full Name
protocadherin gamma subfamily A, 5
Background
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
Synonyms
PCDHGA5; protocadherin gamma subfamily A, 5; protocadherin gamma-A5; cadherin ME3; CDH GAMMA A5; ME3; PCDH GAMMA A5; PCDH-gamma-A5; Protocadherin gamma A5; OTTHUMP00000224533; CDH-GAMMA-A5; MGC142020