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pcdhga11

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Official Full Name
protocadherin gamma subfamily C, 3
Background
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
Synonyms
PCDHGC3; protocadherin gamma subfamily C, 3; PCDH2; protocadherin gamma-C3; cadherin like 2; PC 43; PC43; PCDH GAMMA C3; protocadherin 2; protocadherin 43; PCDH 2; PCDHGC 3; Protocadherin gamma C3; Protocadherin gamma subfamily C 3; Protocadherin2; Protocadherin43; cadherin-like 2; protocadherin-2; protocadherin-43; OTTHUMP00000160013; PCDH-GAMMA-C3; PCDHGC5; PCDHGA11; protocadherin gamma subfamily C, 5; protocadherin gamma subfamily A, 11