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pcdha6

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Official Full Name
protocadherin alpha 6
Background
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
Synonyms
PCDHA6; protocadherin alpha 6; CNRS2; protocadherin alpha-6; CNR2; CRNR2; KIAA0345 like 8; PCDH ALPHA6; Cadherin related neuronal receptor 2; CNR 2; CNRN 2; CNRN2; CNRS 2; CRNR 2; PCDHA 6; PCDH-alpha-6; KIAA0345-like 8; OTTHUMP00000223649; OTTHUMP00000232599; PCDH-ALPHA6