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pcbp4

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Official Full Name
poly(rC) binding protein 4
Background
This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This genes protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined.
Synonyms
PCBP4; poly(rC) binding protein 4; poly(rC)-binding protein 4; alphaCP 4 protein; LIP4; LYST interacting protein; MCG10; RNA binding protein MCG10; Alpha CP4; rCbinding protein 4; alpha-CP4; LYST-interacting protein; CBP

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