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pax2

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Official Full Name
paired box 2
Background
PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor supressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Synonyms
PAX2; paired box 2; PAPRS; paired box protein Pax-2; paired box homeotic gene 2; PAX-2; paired box gene 2; paired-box containing protein Pax-2

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