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pard6a

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Official Full Name
par-6 family cell polarity regulator alpha
Background
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Synonyms
PARD6A; par-6 family cell polarity regulator alpha; PAR6; PAR6C; TAX40; PAR-6A; TIP-40; PAR6alpha; partitioning defective 6 homolog alpha; PAR-6 alpha; Tax-interacting protein 40; tax interaction protein 40; partitioning-defective protein 6; partitioning defective-6 homolog alpha; par-6 partitioning defective 6 homolog alpha; par-6 partitioning defective 6 homolog alpha (C. elegans); par 6 (partitioning defective 6, C.elegans) homolog alpha; PAR 6; PAR 6A; TIP 40; PAR6, PAR6C, TAX40, PAR-6A, TIP-40, PAR6alpha, PARD6A; pard6alpha; si:ch73-186j5.3; partitioning defective 6 alpha