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pappa2

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Official Full Name
pappalysin 2
Background
This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants.
Synonyms
PAPPA2; pappalysin 2; PLAC3, placenta specific 3; pappalysin-2; PAPP A2; PAPPE; PAPP-E; placenta-specific 3; pregnancy-associated plasma protein E1; pregnancy-associated plasma preproprotein-A2; PLAC3; PAPP-A2

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