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padi2

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Official Full Name
peptidyl arginine deiminase, type II
Background
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.
Synonyms
PADI2; peptidyl arginine deiminase, type II; protein-arginine deiminase type-2; KIAA0994; PDI2; OTTHUMP00000044625; PAD 2; PAD H19; PADI 2; PADI2 protein; PDI 2; Peptidlyarginine deiminase type II; Peptidyl arginine deiminase II; Peptidyl arginine deiminase type II; Peptidylarginine deiminase II; Protein arginine deiminase; Protein arginine deiminase type 2; Protein arginine deiminase type II; OTTHUMP00000002403; OTTHUMP00000002404; protein-arginine deiminase type II; PAD2; PAD-H19; sb:cb968; zgc:66317