This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinsons disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinsons disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.
PACRG; PARK2 co-regulated; parkin coregulated gene protein; FLJ32724; Glup; HAK005771; PARK2CRG; Molecular chaperone/chaperonin binding protein; PARK 2 co regulated; PARK 2 coregulated; PARK2 co regulated; PARK2 coregulated; Parkin co regulated gene; Parkin co regulated gene protein; Parkin coregulated gene; RP3 495O10.2; parkin co-regulated gene protein; molecular chaperone/chaperonin-binding protein; RP3-495O10.2; GLUP, PARK2CRG, HAK005771, RP3-495O10.2, PACRG; zgc:101786