|CDCB166282||Chicken P2RX4 ORF Clone (NM_204291)||Inquriy|
|CDCB180837||Rabbit P2RX4 ORF clone (XM_002719744.2)||Inquriy|
|CDCL145283||Mouse P2RX4 ORF clone (NM_002560.2)||Inquriy|
|CDCL145285||Mouse P2RX4 ORF clone (NM_001256796.1)||Inquriy|
|CDCL145287||Mouse P2rx4 ORF clone (NM_011026.2)||Inquriy|
|CDCR379613||Rat P2rx4 ORF Clone(NM_031594.1)||Inquriy|
|CDCS410122||Human P2RX4 ORF Clone (BC033826)||Inquriy|
|CDFH013546||Human P2RX4 cDNA Clone(NM_002560.2)||Inquriy|
|CDFH013547||Human P2RX4 cDNA Clone(NM_002560.2)||Inquriy|
|CDFH013548||Human P2RX4 cDNA Clone(NM_002560.2)||Inquriy|
|CDFL009813||Mouse P2rx4 cDNA Clone(NM_011026.2)||Inquriy|
|CDFR012750||Rat P2rx4 cDNA Clone(NM_031594.1)||Inquriy|
|MiUTR1H-07439||P2RX4 miRNA 3'UTR clone||Inquriy|
|MiUTR1M-08836||P2RX4 miRNA 3'UTR clone||Inquriy|
|MiUTR1R-05575||P2RX4 miRNA 3'UTR clone||Inquriy|
|SHH369476||shRNA set against Human P2RX4 (NM_002560.2)||Inquriy|
|SHH369480||shRNA set against Mouse P2RX4 (NM_011026.2)||Inquriy|
|SHR085038||shRNA set against Human P2RX4(NM_002560.2)||Inquriy|
|SHR085056||shRNA set against Rat P2rx4(NM_031594.1)||Inquriy|
|SHR085092||shRNA set against Mouse P2rx4(NM_011026.2)||Inquriy|
|SHW004807||shRNA set against Chicken P2RX4 (NM_204291)||Inquriy|
P2RX4 and Alcohol Use Disorders
Alcohol use disorders (AUDs) rank third on the list of preventable causes of morbidity in the United States, which is a major national impact that affects over 18 million people and causes over 100,000 deaths annually. Drug development for AUDs is a relatively young field compared to cancer, cardiovascular and psychiatric disorders. Ligand-gated ion channels (LGICs) play an important role in ethanol-induced behaviors and drinking. Within the mammalian CNS, there are two major purinergic receptor families that bind to adenine nucleotides including adenosine 5’-triphosphate (ATP), P2X family of LGICs, and the P2Y family of G protein-coupled receptors. Thus, purinergic P2X receptors (P2RXs) form functional heteromeric or homomeric receptor that modulate the release of other neurotransmitters.
P2RXs are distributed widely within the mammalian CNS in a heterogeneous fashion. P2RX4s localize to the hippocampal pyramidal layers CA1, CA2 and CA3 as well as the granule layers of the dentate gyrus, along with P2RX2s and P2RX6s. P2RX4s is the most robustly expressed functional ATP-gated purinergic receptors in the CNS. In addition to normal levels of expression, the P2RX4 has been reported to be altered by dopamine depletion, specifically in the 6-hydroxydopamine rat model of Parkinson’s disease with decreased expression of SNpc and dorsal striatal GABAergic neurons and increased expression of SNpr GABAergic neurons. P2RX4 represents a novel and largely unexplored target for drug development to prevent AUDs and plays a role in regulating ethanol intake. There is an inverse relationship between P2RX4s activity and ethanol consumption.
Figure 1. The major connections within the reward and aversion circuitry are regulated by P2RX4s either directly or indirectly. (doi: 10.3389/fnins.2014.00176)
Our promise to you:
Guaranteed product quality, expert customer support.
Contact us today for a free consultation with the scientific team and discover how Creative Biogene can be a valuable resource and partner for your organization.