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olig2

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Official Full Name
oligodendrocyte lineage transcription factor 2
Background
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome.
Synonyms
OLIG2; oligodendrocyte lineage transcription factor 2; oligodendrocyte transcription factor 2; wu:fc64g09