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oas2

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Official Full Name
2'-5'-oligoadenylate synthetase 2, 69/71kDa
Background
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2-specific nucleotidyl transfer reactions to synthesize 2,5-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.
Synonyms
OAS2; 2-5-oligoadenylate synthetase 2, 69/71kDa; 2 5 oligoadenylate synthetase 2 (69 71 kD); 2-5-oligoadenylate synthase 2; (2-5)oligo(A) synthetase 2; 2-5-oligoadenylate synthetase 2; 2-5A synthetase 2; MGC78578; p69 OAS / p71 OAS; p69OAS / p71OAS; 2-5A synthase 2

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