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ntsr2

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Official Full Name
neurotensin receptor 2
Background
The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a;phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this;receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However,;unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist;previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that;this receptor may be of physiological importance and that a natural agonist for the receptor may exist.
Synonyms
NTSR2; neurotensin receptor 2; neurotensin receptor type 2; NTR2; NT-R-2; neurotensin receptor, type 2; levocabastine-sensitive neurotensin receptor