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ntrk2

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Official Full Name
neurotrophic tyrosine kinase, receptor, type 2
Background
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms
NTRK2; neurotrophic tyrosine kinase, receptor, type 2; TRKB; trk-B; GP145-TrkB; BDNF/NT-3 growth factors receptor; trkB tyrosine kinase; tyrosine kinase receptor B; tropomyosin-related kinase B; BDNF-tropomyosine receptor kinase B; neurotrophic tyrosine receptor kinase type 2; Tkrb; TRKB1; RATTRKB1; tyrosine kinase receptor; neurotrophic tyrosine kinase receptor type 2

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