Official Full Name
non-SMC element 2, MMS21 homolog (S. cerevisiae)
E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.
NSMCE2; non-SMC element 2, MMS21 homolog (S. cerevisiae); C8orf36, chromosome 8 open reading frame 36 , non SMC element 2 homolog (MMS21, S. cerevisiae); E3 SUMO-protein ligase NSE2; FLJ32440; MMS21; NSE2; C8orf36; hMMS21; hNSE2; methyl methanesulfonate sensitivity gene 21; MMS21 homolog; non-SMC element 2; Non-SMC element 2 homolog; Non-structural maintenance of chromosomes element 2 homolog; NSE2_HUMAN; non-SMC element 2 homolog (MMS21, S. cerevisiae)