This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene.
NSL1; NSL1, MIND kinetochore complex component, homolog (S. cerevisiae); C1orf48, chromosome 1 open reading frame 48; kinetochore-associated protein NSL1 homolog; DC8; DKFZP566O1646; MIS14; 4833432M17Rik; AI451597; C1orf48; DC31; Gm105; Gm984; Kinetochore associated protein NSL1 homolog; NSL1, MIS12 kinetochore complex component; NSL1, MIND kinetochore complex component, homolog; si:ch211-147d7.3