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NR1H4

Official Full Name
nuclear receptor subfamily 1, group H, member 4
Background
This gene encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Synonyms
NR1H4; nuclear receptor subfamily 1, group H, member 4; BAR; FXR; HRR1; HRR-1; RIP14; bile acid receptor; farnesol receptor HRR-1; RXR-interacting protein 14; farnesoid X nuclear receptor; farnesoid X-activated receptor; retinoid X receptor-interacting protein 14; HRR 1; MGC163445; zgc:92742; zgc:110190; FXRalpha

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